Michael Adam

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Michael Adam

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Research and Teaching Interests

RESEARCH PROGRAMME

The PET Chemistry group at TRIUMF has been developing short lived, positron emitting radiotracers for use in PET imaging since 1980. The PET chemistry group prepares several F-18 (t1/2=110 min) and C-11 (t1/2=20 min) labelled radiopharmaceuticals for routine use in our neurology programme as well as developing new agents for Oncology research. We also develop new labeling strategies for the incorporation of a variety of radioisotopes into organic and inorganic compounds. Some of the routinely produced radiopharmaceuticals used in our brain imaging program include C-11 labelled raclopride (D2 receptor antagonist), dihydrotetrabenazine (vesicular monoamine transporter inhibitor) and F-18 labelled fluoro-L-dopa. Radiopharmaceuticals for use in cancer research include F-18 labelled EF5 (nitroimidazole for detecting hypoxia in tumours) and fluoro-deoxy-glucose (FDG).

The PET chemistry group has extensive collaborations with researchers at UBC, UVIC, SFU, BCCA, VGH and local biotech companies such as Nordion. Of particular interest to the UBC Chemistry Department are the collaborations with Drs. Orvig. Withers, and Perrin. The collaboration with Dr. Orvig involves the development of carbohydrate radio-metal conjugates with Tc-99m and Re-186/188 for potential use as imaging and therapy agents. The longstanding collaboration with Dr. Withers focuses on the development of glycosidase inhibitors, labeled with F-18, as potential imaging agents for studying lysosomal storages diseases such as Gaucher’s disease and MPS-1. The collaboration with Dr. Perrin involves the development of new F-18 labelling strategies for the synthesis of novel oligonucleotides and other large biomolecules as potential imaging agents.

Contact

Real name: 
Email: 
Office Room Number(s): 
TRIUMF
Office Phone Number: 
604-222-7527
Fax Number: 
604-222-1074

Curriculum Vitae

B.Sc., University of British Columbia (1975); Ph.D., University of British Columbia (Laurance D. Hall, 1980); TRIUMF Research Scientist (1980); Adjunct Professor of Pharmaceutical Sciences (UBC, 1982-2005); TRIUMF Senior Research Scientist (2003); Adjunct Professor, UBC Chemistry (2005-current). Affiliate member BC Cancer Agency.

Publications

2013

Price, E. W. ; Zeglis, B. M. ; Cawthray, J. F. ; Ramogida, C. F. ; Ramos, N. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H 4 Octapa-Trastuzumab: Versatile Acyclic Chelate System For 111 In And 177 Lu Imaging And Therapy. Journal of the American Chemical Society 2013, 135, 12707 - 12721.
Salas, P. F. ; Herrmann, C. ; Cawthray, J. F. ; Nimphius, C. ; Kenkel, A. ; Chen, J. ; de Kock, C. ; Smith, P. J. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Structural Characteristics Of Chloroquine-Bridged Ferrocenophane Analogues Of Ferroquine May Obviate Malaria Drug-Resistance Mechanisms. Journal of Medicinal Chemistry 2013, 56, 1596 - 1613.

2012

Boros, E. ; Ferreira, C. L. ; Yapp, D. T. T. ; Gill, R. K. ; Price, E. W. ; Adam, M. J. ; Orvig, C. Rgd Conjugates Of The H2Dedpa Scaffold: Synthesis, Labeling And Imaging With 68Ga. Nuclear Medicine and Biology 2012, 39, 785 - 794.
Herrmann, C. ; Salas, P. F. ; Patrick, B. O. ; de Kock, C. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. 1,2-Disubstituted Ferrocenyl Carbohydrate Chloroquine Conjugates As Potential Antimalarial Agents. Dalton Transactions 2012, 41, 6431-6442.
Bailey, G. A. ; Price, E. W. ; Zeglis, B. M. ; Ferreira, C. L. ; Boros, E. ; Lacasse, M. J. ; Patrick, B. O. ; Lewis, J. S. ; Adam, M. J. ; Orvig, C. H 2 Azapa: A Versatile Acyclic Multifunctional Chelator For 67 Ga, 64 Cu, 111 In, And 177 Lu. Inorganic Chemistry 2012, 51, 12575 - 12589.
Herrmann, C. ; Salas, P. F. ; Cawthray, J. F. ; de Kock, C. ; Patrick, B. O. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. 1,1'-Disubstituted Ferrocenyl Carbohydrate Chloroquine Conjugates As Potential Antimalarials. Organometallics 2012, 31, 5736 - 5747.
Herrmann, C. ; Salas, P. F. ; Patrick, B. O. ; de Kock, C. ; Smith, P. J. ; Adam, M. J. ; Orvig, C. Modular Synthesis Of 1,2- And 1,1'-Disubstituted Ferrocenyl Carbohydrate Chloroquine And Mefloquine Conjugates As Potential Antimalarial Agents. Organometallics 2012, 31, 5748 - 5759.
Boros, E. ; Cawthray, J. F. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Evaluation Of The H 2 Dedpa Scaffold And Its Crgdyk Conjugates For Labeling With 64 Cu. Inorganic Chemistry 2012, 51, 6279 - 6284.
Price, E. W. ; Cawthray, J. F. ; Bailey, G. A. ; Ferreira, C. L. ; Boros, E. ; Adam, M. J. ; Orvig, C. H 4 Octapa: An Acyclic Chelator For 111 In Radiopharmaceuticals. Journal of the American Chemical Society 2012, 134, 8670 - 8683.

2011

Scott, L. E. ; Telpoukhovskaia, M. ; Rodríguez-Rodríguez, C. ; Merkel, M. ; Bowen, M. L. ; Page, B. D. G. ; Green, D. E. ; Storr, T. ; Thomas, F. ; Allen, D. D. ; Lockman, P. R. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. N-Aryl-Substituted 3-(Β-D-Glucopyranosyloxy)-2-Methyl-4(1H)-Pyridinones As Agents For Alzheimer’S Therapy. Chemical Science 2011, 2, 642-648.
Boros, E. ; Lin, Y. - H. Scott; Ferreira, C. L. ; Patrick, B. O. ; Häfeli, U. O. ; Adam, M. J. ; Orvig, C. One To Chelate Them All: Investigation Of A Versatile, Bifunctional Chelator For 64Cu, 99Mtc, Re And Co. Dalton Transactions 2011, 40, 6253-6259.
Levine, D. S. ; Metzger, D. L. ; Nadel, H. R. ; Oviedo, A. ; Adam, M. J. ; Skarsgard, E. Novel Use Of F-Dopa Pet/ct Imaging In A Child With Paraganglioma/pheochromocytoma Syndrome. Pediatric Radiology 2011.
Boros, E. ; Ferreira, C. L. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. New Ga Derivatives Of The H2Dedpa Scaffold With Improved Clearance And Persistent Heart Uptake. Nucl. Med. Biol. 2011, 38, 1165-1174.

2010

Ferreira, C. L. ; Marques, F. L. N. ; Okamoto, M. R. Y. ; Otake, A. H. ; Sugai, Y. ; Mikata, Y. ; Storr, T. ; Bowen, M. ; Yano, S. ; Adam, M. J. ; Chammas, R. ; Orvig, C. Cationic Technetium And Rhenium Complexes With Pendant Carbohydrates. Applied Radiation and Isotopes 2010, 68, 1087 - 1093.
Keller, Uauf dem; Bellac, C. L. ; Li, Y. ; Lou, Y. ; Lange, P. F. ; Ting, R. ; Harwig, C. ; Kappelhoff, R. ; Dedhar, S. ; Adam, M. J. ; Ruth, T. J. ; Benard, F. ; Perrin, D. M. ; Overall, C. M. Novel Matrix Metalloproteinase Inhibitor [18F]Marimastat-Aryltrifluoroborate As A Probe For In Vivo Positron Emission Tomography Imaging In Cancer. Cancer Research 2010, 70, 7562 - 7569.
Ferreira, C. L. ; Marques, F. L. N. ; Okamoto, M. R. Y. ; Otake, A. H. ; Sugai, Y. ; Mikata, Y. ; Storr, T. ; Bowen, M. ; Yano, S. ; Adam, M. J. Cationic Technetium And Rhenium Complexes With Pendant Carbohydrates. Applied Radiation and Isotopes 2010, 68, 1087 - 1093.
Yatham, L. N. ; Liddle, P. F. ; Lam, R. W. ; Zis, A. P. ; Stoessl, A. J. ; Sossi, V. ; Adam, M. J. ; Ruth, T. J. Effect Of Electroconvulsive Therapy On Brain 5-Ht2 Receptors In Major Depression. The British Journal of Psychiatry 2010, 196, 474 - 479.
Phenix, C. P. ; Rempel, B. P. ; Colobong, K. ; Doudet, D. J. ; Adam, M. J. ; Clarke, L. A. ; Withers, S. G. Imaging Of Enzyme Replacement Therapy Using Pet. Proceedings of the National Academy of Sciences 2010, 107, 10842 - 10847.
Boros, E. ; Ferreira, C. L. ; Cawthray, J. F. ; Price, E. W. ; Patrick, B. O. ; Wester, D. W. ; Adam, M. J. ; Orvig, C. Acyclic Chelate With Ideal Properties For 68Ga Pet Imaging Agent Elaboration. Journal of the American Chemical Society 2010, 132, 15726 - 15733.

2009

Boros, E. ; Hafeli, U. O. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Design, Synthesis, And Imaging Of Small Amphiphilic Rhenium And (99M)Technetium Tricarbonyl Complexes. Bioconjugate Chemistry 2009, 20, 1002-1009.
Bowen, M. L. ; Lim, N. C. ; Ewart, C. B. ; Misri, R. ; Ferreira, C. L. ; Hafeli, U. ; Adam, M. J. ; Orvig, C. Glucosamine Conjugates Bearing N,n,o-Donors: Potential Imaging Agents Utilizing The [M(Co)(3)](+) Core (M = Re, Tc). Dalton Transactions 2009, 9216-9227.
Bowen, M. L. ; Chen, Z. F. ; Roos, A. M. ; Misri, R. ; Hafeli, U. ; Adam, M. J. ; Orvig, C. Long-Chain Rhenium And Technetium Glucosamine Conjugates. Dalton Transactions 2009, 9228-9236.
Marques, F. L. ; Storr, T. ; Okamoto, M. R. ; Otake, A. H. ; Ferreira, C. L. ; Buchpiguel, C. A. ; Chammas, R. ; Adam, M. J. ; Orvig, C. Pedant 991 Tricarbonil Or Bisoxo Diamine Complexes Of Carbohydrates As Potential Tumor Spect Imaging Agent. Journal of Labelled Compounds & Radiopharmaceuticals 2009, 52, S277-S277.
Phenix, C. P. ; Rempel, B. P. ; Adam, M. J. ; Withers, S. G. A Potential Method To Monitor Enzyme Replacement Therapy For Treatment Of Gaucher Disease Using Pet. Journal of Labelled Compounds & Radiopharmaceuticals 2009, 52, S104-S104.

2008

Ting, R. ; Harwig, C. ; U. Keller, aufdem; McCormick, S. ; Austin, P. ; Overall, C. M. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Toward [F-18]-Labeled Aryltrifluoroborate Radiotracers: In Vivo Positron Emission Tomography Imaging Of Stable Aryltrifluoroborate Clearance In Mice. Journal of the American Chemical Society 2008, 130, 12045-12055.
Ting, R. ; Lo, J. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Capturing Aqueous [F-18]-Fluoride With An Arylboronic Ester For Pet: Synthesis And Aqueous Stability Of A Fluorescent [F-18]-Labeled Aryltrifluoroborate. Journal of Fluorine Chemistry 2008, 129, 349-358.
Ting, R. ; Harwig, C. W. ; Lo, J. ; Li, Y. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Substituent Effects On Aryltrifluoroborate Solvolysis In Water: Implications For Suzuki-Miyaura Coupling And The Design Of Stable F-18-Labeled Aryltrifluoroborates For Use In Pet Imaging. Journal of Organic Chemistry 2008, 73, 4662-4670.
Lim, N. C. ; Ewart, C. B. ; Bowen, M. L. ; Ferreira, C. L. ; Barta, C. A. ; Adam, M. J. ; Orvig, C. Pyridine-Tert-Nitrogen-Phenol Ligands: N,n,o-Type Tripodal Chelates For The [M(Co)(3)](+) Core (M = Re, Tc). Inorganic Chemistry 2008, 47, 1337-1345.

2007

Ferreira, C. L. ; Lapi, S. ; Steele, J. ; Green, D. E. ; Ruth, T. J. ; Adam, M. J. ; Orvig, C. (55)Cobalt Complexes With Pendant Carbohydrates As Potential Pet Imaging Agents. Applied Radiation and Isotopes 2007, 65, 1303-1308.

2006

Ferreira, C. L. ; Bayly, S. R. ; Green, D. E. ; Storr, T. ; Barta, C. A. ; Steele, J. ; Adam, M. J. ; Orvig, C. Carbohydrate-Appended 3-Hydroxy-4-Pyridinone Complexes Of The [M(Co)(3)](+) Core (M) Re, Tc-99M, Re-186). Bioconjugate Chemistry 2006, 17, 1321-1329.
Ferreira, C. L. ; Ewart, C. B. ; Barta, C. A. ; Little, S. ; Yardley, V. ; Martins, C. ; Polishchuk, E. ; Smith, P. J. ; Moss, J. R. ; Merkel, M. ; Adam, M. J. ; Orvig, C. Synthesis, Structure, And Biological Activity Of Ferrocenyl Carbohydrate Conjugates. Inorganic Chemistry 2006, 45, 8414-8422.
Ferreira, C. L. ; Ewart, C. B. ; Bayly, S. R. ; Patrick, B. O. ; Steele, J. ; Adam, M. J. ; Orvig, C. Glucosamine Conjugates Of Tricarbonylcyclopentadienyl Rhenium(I) And Technetium(I) Cores. Inorganic Chemistry 2006, 45, 6979-6987.

2005

Ting, R. ; Adam, M. J. ; Ruth, T. J. ; Perrin, D. M. Arylfluoroborates And Alkylfluorosilicates As Potential Pet Imaging Agents: High-Yielding Aqueous Biomolecular F-18-Labeling. Journal of the American Chemical Society 2005, 127, 13094-13095.
Green, D. E. ; Ferreira, C. L. ; Stick, R. V. ; Patrick, B. O. ; Adam, M. J. ; Orvig, C. Carbohydrate-Bearing 3-Hydroxy-4-Pyridinonato Complexes Of Gallium(Iii) And Indium(Iii). Bioconjugate Chemistry 2005, 16, 1597-1609.
Storr, T. ; Obata, M. ; Fisher, C. L. ; Bayly, S. R. ; Green, D. E. ; Brudzinska, I. ; Mikata, Y. ; Patrick, B. O. ; Adam, M. J. ; Yano, S. ; Orvig, C. Novel Carbohydrate-Appended Metal Complexes For Potential Use In Molecular Imaging. Chemistry-a European Journal 2005, 11, 195-203.
Storr, T. ; Sugai, Y. ; Barta, C. A. ; Mikata, Y. ; Adam, M. J. ; Yano, S. ; Orvig, C. Carbohydrate-Appended 2,2 ’-Dipicolylamine Metal Complexes As Potential Imaging Agents. Inorganic Chemistry 2005, 44, 2698-2705.
Storr, T. ; Fisher, C. L. ; Mikata, Y. ; Yano, S. ; Adam, M. J. ; Orvig, C. A Glucosamine Dipicolylamine Conjugate Of Tc-99M(I) And Re-186(I) For Use In Imaging And Therapy. Dalton Transactions 2005, 654-655.
Adam, M. J. ; Wilbur, D. S. Radiohalogens For Imaging And Therapy. Chemical Society Reviews 2005, 34, 153-163.

2004

Bayly, S. R. ; Fisher, C. L. ; Storr, T. ; Adam, M. J. ; Orvig, C. Carbohydrate Conjugates For Molecular Imaging And Radiotherapy: Tc-99M(I) And Re-186(I) Tricarbonyl Complexes Of N-(2 ’-Hydroxybenzyl)-2-Amino-2-Deoxy-D-Glucose. Bioconjugate Chemistry 2004, 15, 923-926.

2001

Wong, A. W. ; Adam, M. J. ; Withers, S. G. Synthesis Of 2,6-Dideoxy-2-Fluoro-6-[F-18]-Fluoro-Beta-D-Glucopyranosyl Fluoride (2,6Fgf) As A Potential Imaging Probe For Glucocerebrosidase. Journal of Labelled Compounds & Radiopharmaceuticals 2001, 44, 385-394.

1995

McCarter, J. D. ; Adam, M. J. ; Withers, S. G. Syntheses, Radiolabeling, And Kinetic Evaluation Of 2-Deoxy-2-Fluoro-2-Iodo-D-Hexoses For Medical Imaging. Carbohydrate Research 1995, 266, 273-277.

1994

1993

McCarter, J. D. ; Adam, M. J. ; Braun, C. ; Namchuk, M. ; Tull, D. ; Withers, S. G. Syntheses Of 2-Deoxy-2-Fluoro Monosaccharide And Oligosaccharide Glycosides From Glycals And Evaluation As Glycosidase Inhibitors. Carbohydrate Research 1993, 249, 77-90.
Adam, M. J. ; McCarter, J. ; Hartman, N. ; Hewitt, K. ; Withers, S. G. 2-Deoxy-2-F-18-Fluoro-Mannosyl-F-18-Fluoride (2Fdmf) As A Potential Pet Imaging Agent For Brain Glycosidases - Biodistribution And Tissue-Assays. Journal of Nuclear Medicine 1993, 34, P242-P242.

1992

McCarter, J. D. ; Adam, M. J. ; Withers, S. G. Synthesis Of 2-Deoxy-2-[F-18]-Fluoro-Beta-Mannosyl [F-18] Fluoride As A Potential Imaging Probe For Glycosidases. Journal of Labelled Compounds & Radiopharmaceuticals 1992, 31, 1005-1009.

1989

Balatoni, J. A. ; Adam, M. J. ; Hall, L. D. Synthesis Of C-11-Labeled Aromatics Using Aryl Chromium Tricarbonyl Intermediates. Journal of Labelled Compounds & Radiopharmaceuticals 1989, 27, 1429-1435.

1986

Balatoni, J. A. ; Adam, M. J. ; Brule, M. ; Hall, L. D. Synthesis Of Nca C-11 Labeled Aromatics Using C-11 Cyanide And Aryl-Chromium Tricarbonyl Intermediates. Journal of Labelled Compounds & Radiopharmaceuticals 1986, 23, 1054-1054.
Balatoni, J. A. ; Adam, M. J. ; Hall, L. D. Synthesis Of Halogenated Vinylcarbohydrate And Vinyl-Estradiol Derivatives By The Cleavage Of Vinyl-Tin Bonds. Journal of Nuclear Medicine 1986, 27, 972-972.

1985

1983

Adam, M. J. ; Pate, B. D. ; Nesser, J. R. ; Hall, L. D. A Rapid, Stereoselective Synthesis Of Fluorinated Carbohydrates - Addition Of Acetyl Hypofluorite To Vinyl Ether Derivatives Of Sugars. Carbohydrate Research 1983, 124, 215-224.

1982

Adam, M. J. ; Ruth, T. J. ; Pate, B. D. ; Hall, L. D. Site-Specific Bromination Of Aromatic-Compounds - A Rapid Method For Radiobromine Labeling. Journal of the Chemical Society-Chemical Communications 1982, 625-626.
Adam, M. J. ; Hall, L. D. Synthesis Of Metal-Chelates Of Amino-Sugars - Schiffs Base Complexes. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1982, 60, 2229-2237.

1981

Adam, M. J. ; Pate, B. D. ; Ruth, T. J. ; Berry, J. M. ; Hall, L. D. Cleavage Of Aryl-Tin Bonds With Elemental Fluorine - Rapid Synthesis Of [F-18] Fluorobenzene. Journal of the Chemical Society-Chemical Communications 1981, 733-733.

1980

Adam, M. J. ; Hall, L. D. Synthesis Of Sugar-Organometallic Conjugates - Ferrocenyl Monosaccharide Derivatives. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1980, 58, 1188-1197.

1979

Adam, M. J. ; Hall, L. D. Covalent, Nitroxide Spin-Labeling Of Carbohydrates Via S-Triazine Residues. Carbohydrate Research 1979, 68, C17-C20.
Adam, M. J. ; Hall, L. D. General-Synthesis Of Chelate Conjugates Of Amino-Sugars And Metals - Salicylideneamine Schiff-Bases. Journal of the Chemical Society-Chemical Communications 1979, 234-235.
Adam, M. J. ; Hall, L. D. Synthesis Of Sugar Organometallic Conjugates - Ferrocenyl Derivatives. Journal of the Chemical Society-Chemical Communications 1979, 865-866.