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Massetolides A-H, antimycobacterial cyclic depsipeptides produced by two pseudomonads isolated from marine habitats

TitleMassetolides A-H, antimycobacterial cyclic depsipeptides produced by two pseudomonads isolated from marine habitats
Publication TypeJournal Article
Year of Publication1997
AuthorsGerard, J, Lloyd, R, Barsby, T, Haden, P, Kelly, MT, Andersen, RJ
JournalJournal of Natural Products
Volume60
Pagination223-229
Date PublishedMar
Type of ArticleArticle
ISBN Number0163-3864
KeywordsBACTERIA, biosynthesis, METABOLITES
Abstract

Massetolides A-H (1-8), novel cyclic depsipetides, and the known compound viscosin (9) have been isolated from cultures of two Pseudomonas sp. isolated from a marine alga and a marine tube worm, respectively. Massetolide A (1) and viscosin (9) exhibit in vitro antimicrobial activity against Mycobacterium tuberculosis and Mycobacterium avium-intracellulare. Precursor-directed biosynthesis has been used to generate unnatural massetolides 11-13 incorporating nonprotein amino acids.

URL<Go to ISI>://A1997WP60300006