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Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium

TitleLoloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium
Publication TypeJournal Article
Year of Publication1999
AuthorsGerard, JM, Haden, P, Kelly, MT, Andersen, RJ
JournalJournal of Natural Products
Volume62
Pagination80-85
Date PublishedJan
Type of ArticleArticle
ISBN Number0163-3864
Abstract

Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae.

URL<Go to ISI>://000078186300014