J Kizhakkedathu

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J Kizhakkedathu


Research and Teaching Interests

Macromolecular Therapeutics: Polymer Cell Derivatization Technology (Universal blood donor cells and Cell based therapeutic carriers): Development of Blood Compatible Surface Coatings: Development of Polymeric Reagents for Proteomic Applications: Please see Centre for Blood Research (CBR) website or Pathology website for more information.


Real name: 
Office Room Number(s): 
4408 Life Sciences Centre
Office Phone Number: 
Fax Number: 

Curriculum Vitae

Ph.D. (Chemistry), Indian Institute of Chemical Technology, 2000 M.Sc. (Chemistry), Mahatma Gandhi University, India, 1994 B.Sc. (Chemistry), Mahatma Gandhi University, India, 1992



Zou, Y. ; Lam, A. ; Brooks, D. E. ; A Phani, S. ; Kizhakkedathu, J. N. Bending And Stretching Actuation Of Soft Materials Through Surface-Initiated Polymerization. Angewandte Chemie (International ed. in English) 2011, 50, 5116-9.
Gao, G. ; Lange, D. ; Hilpert, K. ; Kindrachuk, J. ; Zou, Y. ; Cheng, J. T. J. ; Kazemzadeh-Narbat, M. ; Yu, K. ; Wang, R. ; Straus, S. K. ; Brooks, D. E. ; Chew, B. H. ; Hancock, R. E. W. ; Kizhakkedathu, J. N. The Biocompatibility And Biofilm Resistance Of Implant Coatings Based On Hydrophilic Polymer Brushes Conjugated With Antimicrobial Peptides. Biomaterials 2011, 32, 3899-909.
Ye, L. ; Letchford, K. ; Heller, M. ; Liggins, R. ; Guan, D. ; Kizhakkedathu, J. N. ; Brooks, D. E. ; Jackson, J. K. ; Burt, H. M. Synthesis And Characterization Of Carboxylic Acid Conjugated, Hydrophobically Derivatized, Hyperbranched Polyglycerols As Nanoparticulate Drug Carriers For Cisplatin. Biomacromolecules 2011, 12, 145-55.
Beaudette, P. ; Rossi, N. A. A. ; Huesgen, P. F. ; Yu, X. ; Shenoi, R. A. ; Doucet, A. ; Overall, C. M. ; Kizhakkedathu, J. N. Development Of Soluble Ester-Linked Aldehyde Polymers For Proteomics. Analytical chemistry 2011.
Doucet, A. ; Kleifeld, O. ; Kizhakkedathu, J. N. ; Overall, C. M. Identification Of Proteolytic Products And Natural Protein N-Termini By Terminal Amine Isotopic Labeling Of Substrates (Tails). Methods in molecular biology (Clifton, N.J.) 2011, 753, 273-87.


Rossi, N. A. A. ; Constantinescu, I. ; Brooks, D. E. ; Scott, M. D. ; Kizhakkedathu, J. N. Enhanced Cell Surface Polymer Grafting In Concentrated And Nonreactive Aqueous Polymer Solutions. Journal of the American Chemical Society 2010, 132, 3423-30.
Kleifeld, O. ; Doucet, A. ; Keller, Uauf dem; Prudova, A. ; Schilling, O. ; Kainthan, R. K. ; Starr, A. E. ; Foster, L. J. ; Kizhakkedathu, J. N. ; Overall, C. M. Isotopic Labeling Of Terminal Amines In Complex Samples Identifies Protein N-Termini And Protease Cleavage Products. Nature biotechnology 2010, 28, 281-8.
Zou, Y. ; Yeh, P. - Y. J. ; Rossi, N. A. A. ; Brooks, D. E. ; Kizhakkedathu, J. N. Nonbiofouling Polymer Brush With Latent Aldehyde Functionality As A Template For Protein Micropatterning. Biomacromolecules 2010, 11, 284-93.
Zou, Y. ; Lai, B. F. L. ; Kizhakkedathu, J. N. ; Brooks, D. E. Inhibitory Effect Of Hydrophilic Polymer Brushes On Surface-Induced Platelet Activation And Adhesion. Macromolecular bioscience 2010, 10, 1432-43.
Lai, B. F. L. ; Zou, Y. ; Brooks, D. E. ; Kizhakkedathu, J. N. The Influence Of Poly-N-[(2,2-Dimethyl-1,3-Dioxolane)Methyl]Acrylamide On Fibrin Polymerization, Cross-Linking And Clot Structure. Biomaterials 2010, 31, 5749-58.
Lai, B. F. L. ; A Creagh, L. ; Janzen, J. ; Haynes, C. A. ; Brooks, D. E. ; Kizhakkedathu, J. N. The Induction Of Thrombus Generation On Nanostructured Neutral Polymer Brush Surfaces. Biomaterials 2010, 31, 6710-8.
Kizhakkedathu, J. N. ; A Creagh, L. ; Shenoi, R. A. ; Rossi, N. A. A. ; Brooks, D. E. ; Chan, T. ; Lam, J. ; Dandepally, S. R. ; Haynes, C. A. High Molecular Weight Polyglycerol-Based Multivalent Mannose Conjugates. Biomacromolecules 2010, 11, 2567-75.
Rossi, N. A. A. ; Constantinescu, I. ; Kainthan, R. K. ; Brooks, D. E. ; Scott, M. D. ; Kizhakkedathu, J. N. Red Blood Cell Membrane Grafting Of Multi-Functional Hyperbranched Polyglycerols. Biomaterials 2010, 31, 4167-78.


Rossi, N. A. A. ; Mustafa, I. ; Jackson, J. K. ; Burt, H. M. ; Horte, S. A. ; Scott, M. D. ; Kizhakkedathu, J. N. In Vitro Chelating, Cytotoxicity, And Blood Compatibility Of Degradable Poly(Ethylene Glycol)-Based Macromolecular Iron Chelators. Biomaterials 2009, 30, 638-48.
Kizhakkedathu, J. N. ; Janzen, J. ; Le, Y. ; Kainthan, R. K. ; Brooks, D. E. Poly(Oligo(Ethylene Glycol)Acrylamide) Brushes By Surface Initiated Polymerization: Effect Of Macromonomer Chain Length On Brush Growth And Protein Adsorption From Blood Plasma. Langmuir : the ACS journal of surfaces and colloids 2009, 25, 3794-801.


Yeh, P. Ying; Le, Y. ; Kizhakkedathu, J. N. ; Chiao, M. An Investigation Of Vibration-Induced Protein Desorption Mechanism Using A Micromachined Membrane And Pzt Plate. Biomedical microdevices 2008, 10, 701-8.
Yeh, P. - Y. J. ; Kainthan, R. K. ; Zou, Y. ; Chiao, M. ; Kizhakkedathu, J. N. Self-Assembled Monothiol-Terminated Hyperbranched Polyglycerols On A Gold Surface: A Comparative Study On The Structure, Morphology, And Protein Adsorption Characteristics With Linear Poly(Ethylene Glycol)S. Langmuir : the ACS journal of surfaces and colloids 2008, 24, 4907-16.
Kainthan, R. K. ; Janzen, J. ; Kizhakkedathu, J. N. ; Devine, D. V. ; Brooks, D. E. Hydrophobically Derivatized Hyperbranched Polyglycerol As A Human Serum Albumin Substitute. Biomaterials 2008, 29, 1693-704.


Yeh, P. - Y. J. ; Kizhakkedathu, J. N. ; Madden, J. D. ; Chiao, M. Electric Field And Vibration-Assisted Nanomolecule Desorption And Anti-Biofouling For Biosensor Applications. Colloids and surfaces. B, Biointerfaces 2007, 59, 67-73.
Coad, B. R. ; Kizhakkedathu, J. N. ; Haynes, C. A. ; Brooks, D. E. Synthesis Of Novel Size Exclusion Chromatography Support By Surface Initiated Aqueous Atom Transfer Radical Polymerization. Langmuir : the ACS journal of surfaces and colloids 2007, 23, 11791-803.
Coad, B. R. ; Steels, B. M. ; Kizhakkedathu, J. N. ; Brooks, D. E. ; Haynes, C. A. The Influence Of Grafted Polymer Architecture And Fluid Hydrodynamics On Protein Separation By Entropic Interaction Chromatography. Biotechnology and bioengineering 2007, 97, 574-87.


Kainthan, R. Kumar; Gnanamani, M. ; Ganguli, M. ; Ghosh, T. ; Brooks, D. E. ; Maiti, S. ; Kizhakkedathu, J. N. Blood Compatibility Of Novel Water Soluble Hyperbranched Polyglycerol-Based Multivalent Cationic Polymers And Their Interaction With Dna. Biomaterials 2006, 27, 5377-90.
Khan, J. Ahmad; Kainthan, R. Kumar; Ganguli, M. ; Kizhakkedathu, J. N. ; Singh, Y. ; Maiti, S. Water Soluble Nanoparticles From Peg-Based Cationic Hyperbranched Polymer And Rna That Protect Rna From Enzymatic Degradation. Biomacromolecules 2006, 7, 1386-8.