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Isoarenarol, a new protein kinase inhibitor from the marine sponge Dysidea arenaria

TitleIsoarenarol, a new protein kinase inhibitor from the marine sponge Dysidea arenaria
Publication TypeJournal Article
Year of Publication2003
AuthorsYoo, HD, Leung, D, Sanghara, J, Daley, D, Van Soest, R, Andersen, RJ
JournalPharmaceutical Biology
Volume41
Pagination223-225
Date PublishedJun
Type of ArticleArticle
ISBN Number1388-0209
KeywordsAVAROL, hydroquinone, kinase inhibitor, marine sponge, Papua New Guinea, sesquiterpene
Abstract

The novel sesquiterpene hydroquinone isoarenarol (1) and the known compound arenarol (2) were isolated from extracts of the marine sponge Dysidea arenaria Bergquist as part of a search for new protein kinase inhibitors. Both 1 and 2 showed potent and selective protein kinase inhibition in vitro.

URL<Go to ISI>://000184898600001