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Iron(III)-binding of the anticancer agents doxorubicin and vosaroxin

TitleIron(III)-binding of the anticancer agents doxorubicin and vosaroxin
Publication TypeJournal Article
Year of Publication2015
AuthorsMjos, KDralle, Cawthray, JF, Jamieson, G, Fox, JA, Orvig, C
JournalDalton Trans.
Volume44
Pagination2348-2358
Type of ArticleArticle
ISSN1477-9226
Abstract

{The Fe(III)-binding constant of vosaroxin, an anticancer quinolone derivative, has been determined spectrophotometrically and compared with the analogous Fe(III) complex formed with doxorubicin. The in vivo metabolic stability and iron coordination properties of the quinolones compared to the anthracylines may provide significant benefit to cardiovascular safety. The mechanism of action of both molecules target the topoisomerase II enzyme. Both doxorubicin (Hdox, log beta(FeL3) = 33.41

DOI10.1039/c4dt02934h
Refereed DesignationRefereed