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Inhibition of the G(2) DNA damage checkpoint by oliveroline isolated from Duguetia odorata

TitleInhibition of the G(2) DNA damage checkpoint by oliveroline isolated from Duguetia odorata
Publication TypeJournal Article
Year of Publication2007
AuthorsBrastianos, HC, Sturgeon, CM, Roberge, M, Andersen, RJ
JournalJournal of Natural Products
Volume70
Pagination287-288
Date PublishedFeb
ISBN Number0163-3864
Abstract

Plant extracts obtained from the U.S. National Cancer Institute’s Open Repository collection have been screened for their ability to inhibit the G(2) DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G(2) checkpoint inhibitory activity of the D. odorata extract. The new alkaloid N-methylguatterine (2) was identified during this investigation.

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