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Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata

TitleIndoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific marine hydroid Garveia annulata
Publication TypeJournal Article
Year of Publication2006
AuthorsPereira, A, Vottero, E, Roberge, M, Mauk, AG, Andersen, RJ
JournalJournal of Natural Products
Volume69
Pagination1496-1499
Date PublishedOct
Type of ArticleArticle
ISBN Number0163-3864
KeywordsCANCER, chemotherapy, ENZYME, HUMAN LENS, MECHANISM, METABOLITES, NUCLEAR CATARACT, REJECTION, TOLERANCE, TRYPTOPHAN DEGRADATION
Abstract

Crude extracts of the marine hydroid Garveia annulata show potent inhibition of indoleamine 2,3-dioxygenase (IDO). Fractionation of the extract led to the identification of the new polyketides annulin C (1), 2-hydroxygarveatin E (4), garveatin E (5), and garvin C (9). Annulins A (2), B (3), and C (1) were found to be submicromolar inhibitors of IDO.

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