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Improved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C

TitleImproved synthesis of isogranulatimide, a G2 checkpoint inhibitor. Syntheses of didemnimide C, isodidemnimide A, neodidemnimide A, 17-methylgranulatimide, and isogranulatimides A-C
Publication TypeJournal Article
Year of Publication2000
AuthorsPiers, E, Britton, R, Andersen, RJ
JournalJournal of Organic Chemistry
Volume65
Pagination530-535
Date PublishedJan
Type of ArticleArticle
ISBN Number0022-3263
KeywordsBHK CELLS, CAFFEINE, CANCER, CELL-CYCLE CHECKPOINTS, CISPLATIN, DERIVATIVES, DNA-REPLICATION, ENHANCEMENT, IMIDAZOLES, RADIOSENSITIZATION
Abstract

A concise, improved synthesis of isogranulatimide (6), a naturally occurring substance with G2 checkpoint inhibition activity, is described. Also reported are the syntheses of didemnimide C (18), isodidemnimide A (24), neodidemnimide A (36), 17-methylgranulatimide (9), and isogranulatimides A (10), B (11), and C (12). Compounds 9-12, congeners of isogranulatimide (6), are now available for biological evaluation.

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