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Heck reaction of amino acid derived vinyl substrates in the synthesis of homotyrosinol derivatives.

TitleHeck reaction of amino acid derived vinyl substrates in the synthesis of homotyrosinol derivatives.
Publication TypeJournal Article
Year of Publication2010
AuthorsLiang, H, Zhou, Y, Ciufolini, MA
JournalSynthesis
Pagination2515 - 2520
Date Published2010///
ISBN Number0039-7881
Keywordsamino acid vinylglycinol Heck coupling iodophenyl acetate palladium phenylurea, homotyrosinol deriv prepn
Abstract

An avenue to homotyrosinol derivs. through a Heck coupling of 4-iodophenyl acetate with a vinylglycinol deriv. required extensive screening of catalysts and conditions. The use of Pd(OAc)2 and N-phenylurea as the ligand ultimately provided excellent results. [on SciFinder(R)]