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A GENERAL SYNTHETIC ROUTE TO A-RING HYDROXYLATED VITAMIN-D ANALOGS FROM PENTOSES

TitleA GENERAL SYNTHETIC ROUTE TO A-RING HYDROXYLATED VITAMIN-D ANALOGS FROM PENTOSES
Publication TypeJournal Article
Year of Publication1995
AuthorsMoriarty, RM, KIM, J, Brumer, H
JournalTETRAHEDRON LETTERS
Volume36
Pagination51-54
Date PublishedJAN 2
Type of ArticleArticle
ISSN0040-4039
Abstract

The enzyne needed for coupling to a CD-ring fragment, namely, 3S, 5R-oct-1-en-7-yne-3,5-diol, in the Trost-Dumas carbopalladation route to 1 alpha, 25-dihydroxyvitamin D-3 was synthesized from D-xylose in 13 steps and 21% yield.

DOI10.1016/0040-4039(94)02209-T