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Gallium(III) and iron(III) complexes of quinolone antimicrobials

TitleGallium(III) and iron(III) complexes of quinolone antimicrobials
Publication TypeJournal Article
Year of Publication2016
AuthorsMjos, KDralle, Cawthray, JF, Polishchuk, E, Abrams, MJ, Orvig, C
JournalDalton Trans.
Volume45
Pagination13146-13160
Date PublishedSEP 7
ISSN1477-9226
Abstract

Iron is an essential nutrient for many microbes. According to the ``Trojan Horse Hypothesis{''}, biological systems have difficulties distinguishing between Fe3+ and Ga3+, which constitutes the antimicrobial efficacy of the gallium(III) ion. Nine novel tris(quinolono)gallium(III) complexes and their corresponding iron(III) analogs have been synthesized and fully characterized. Quinolone antimicrobial agents from three drug generations were used in this study: ciprofloxacin, enoxacin, fleroxacin, levofloxacin, lomefloxacin, nalidixic acid, norfloxacin, oxolinic acid, and pipemidic acid. The antimicrobial efficacy of the tris(quinolono) gallium(III) complexes was studied against E. faecalis and S. aureus (both Gram-positive), as well as E. coli, K. pneumonia, and P. aeruginosa (all Gram-negative) in direct comparison to the tris(quinolono)iron(III) complexes and the corresponding free quinolone ligands at various concentrations. For the tris(quinolono) gallium(III) complexes, no combinational antimicrobial effects between Ga3+ and the quinolone antimicrobial agents were observed.

DOI10.1039/c6dt01315e