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A formal construction of fasicularin

TitleA formal construction of fasicularin
Publication TypeJournal Article
Year of Publication2003
AuthorsFenster, MDB, Dake, GR
JournalOrganic Letters
Volume5
Pagination4313-4316
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
Keywords(+/-)-LEPADIFORMINE, CROSS-COUPLING, CYLINDRICINE, DIELS-ALDER REACTION, DIPOLAR CYCLOADDITION, ENANTIOMER, KETONES, MARINE ALKALOID LEPADIFORMINE, NATURAL, reaction, REARRANGEMENT, STEREOSELECTIVE CONSTRUCTION
Abstract

Our synthetic approach toward fasicularin is presented. Key steps in this construction are a siloxy-epoxide semipinacol rearrangement, a B-alkyl Suzuki reaction and an intramolecular S(N)2 reaction.

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