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Evidence for de novo biosynthesis of the polyketide fragment of diaulusterol a by the northeastern Pacific Dorid nudibranch Diaulula sandiegensis

TitleEvidence for de novo biosynthesis of the polyketide fragment of diaulusterol a by the northeastern Pacific Dorid nudibranch Diaulula sandiegensis
Publication TypeJournal Article
Year of Publication1999
AuthorsKubanek, J, Andersen, RJ
JournalJournal of Natural Products
Volume62
Pagination777-779
Date PublishedMay
Type of ArticleArticle
ISBN Number0163-3864
KeywordsDEFENSE, ISOTOPE INCORPORATION EVIDENCE, MARINE MOLLUSKS, TRIOPHAMINE
Abstract

Stable isotope incorporation experiments using sodium [1,2-C-13(2)]acetate have demonstrated that the 3-hydroxybutyrate substituent of diaulusterol A (1) is biosynthesized de novo by the dorid nudibranch Diaulula sandiegensis. There was no evidence for acetate incorporation into the steroid portion of 1, nor were radiolabeled mevalonate or cholesterol incorporated.

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