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Electrospray ionization source geometry for mass spectrometry: past, present, and future

TitleElectrospray ionization source geometry for mass spectrometry: past, present, and future
Publication TypeJournal Article
Year of Publication2006
AuthorsManisali, I, Chen, DDY, Schneider, BB
JournalTrac-Trends in Analytical Chemistry
Volume25
Pagination243-256
Date PublishedMar
Type of ArticleReview
ISBN Number0165-9936
KeywordsANALYSIS SYSTEMS, atmospheric pressure ionization, ATMOSPHERIC-PRESSURE, CAPILLARY-ZONE-ELECTROPHORESIS, CHARGED DROPLETS, commercial ion source design, electrospray ionization, ion source, ion source geometry, mass, MICRO-ELECTROSPRAY, MICROFLUIDIC DEVICES, NANOSCALE LIQUID-CHROMATOGRAPHY, PRESSURE ION LENS, PROTEIN IDENTIFICATION, SOLUTION FLOW-RATES, SPECTROMETRY
Abstract

The geometry of an electrospray ion source plays important roles in the processes of analyte desolvation, ionization, transportation, and detection in a mass spectrometer. We provide a brief account of the scientific principles involved in developing an electrospray ion source, and in the various geometries used to improve the sensitivity of mass spectrometry. We also present some popular configurations currently available and outline future trends in this research area. (C) 2005 Elsevier Ltd. All rights reserved.

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