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Diterpenoids from cultured Erythropodium caribaeorum

TitleDiterpenoids from cultured Erythropodium caribaeorum
Publication TypeJournal Article
Year of Publication2002
AuthorsTaglialatela-Scafati, O, Deo-Jangra, U, Campbell, M, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume4
Pagination4085-4088
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsELEUTHEROBIN, ERYTHROLIDES, HALICHONDRIN-B, PHARMACOPHORE, REARRANGEMENT
Abstract

[GRAPHICS] The known antimitotic agent eleutherobin and the briarane diterpenoids erythrolides A and B have been isolated from cultured specimens of Erythropodium caribaeorum in amounts,comparable to those reported from wild-harvested reef animals. The novel diterpenoid aquariolide A, having an unprecedented highly-rearranged carbon skeleton (named aquariane), has also been found. The aquariane skeleton can be formally derived from the briarane-skeleton by sequential di-pi-methane and vinyl-cyclopropane rearrangements.

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