David Chen

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David Chen

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Research and Teaching Interests

Our research program is built on the premise that chemical separation is driven by physical field and chemical equilibrium.  With the insights into how molecules are separated and detected in capillary columns, we wish to design novel instrument that can provide even more separation power for chemical analysis and purification.  Interestingly, the newly designed instrument comes with newly created problems to be solved, and new phenomena to be explained.  Our group enjoys meeting these challenges with many wonderful tools available to us, including what we have learned in physics, mathematics, computer science, and most importantly, chemistry!  We have several projects currently being worked on:

Interface development for capillary electrophoresis- electrospray ionization – mass spectrometry (CE-ESI-MS)
Currently available interfaces suffer from several deficiencies stemmed from the lack of understanding of the fundamental processes involved in CE and MS separately, as well as when the two techniques are interfaced. By playing with the shape and geometry of the sprayer, the chemical properties of the surfaces, solution compositions and the electrical circuits that drive the processes we are developing novel CE-MS interfaces that we hope will give improved performance in both the separation and detection.

Electrophoretic strategies for the purification of biomolecules
In this project we are designing novel instrumentation for larger scale purification systems based on the infinite resolution theory we developed in the past.  By balancing the electrophoretic and hydrodynamic forces acting on analytes in solution, we can selectively manipulate their trajectory.  Having established this technology in single capillaries, we are now working to understand how we can use novel geometries to improve the capacity and yield of purification.

Affinity capillary electrophoresis for the characterization of biochemical interactions
Capillary electrophoresis is an excellent tool for studying biochemical interactions because the separation environment can be tailored to simulate in vivo conditions.  Our group has developed several different techniques that can be used to determine the binding constants based on simple affinity CE experiments.  In addition to applying this technology to many important biological problems, we have also developed software that allows us to visualize what is occurring in the capillary at every stage of an affinity separation, and to predict future results.  The focus now is on improving the predictive ability of the software to allow us to study more complex interactions.

Quantitative investigation of anesthetic agents and markers of oxidative stress in human blood
This project is in collaboration with a Dr. David Ansley at the Vancouver General Hospital, and is designed to study the dose-dependent cardioprotective potential mechanism of propofol. We have developed a quantitative capillary electrophoresis based method to get an accurate picture of how the concentration of anesthetic in a patient’s blood can affect their resilience to oxidative stress and subsequent recovery.

With the beautiful weather in the summer and mild temperature all year round, Vancouver is the most attractive place in North America to live and study. Our group is truly blessed with a very exciting environment to grow both academically and personally.

Prospective students?
We are always welcoming enthusiastic individuals into our lab.  Although our focus is on chemical separations, diverse backgrounds including physics, math, computer studies and biology all have a chance to make unique contributions.   The only pre-requisite is a willingness to learn.  Interested students should contact David at .

David D. Y.Chen Google Scholar Citations

Contact

Real name: 
Email: 
Office Room Number(s): 
Chemistry A347
Office Phone Number: 
604-822-0878

Curriculum Vitae

B.Sc., Xiamen (1985); Ph.D., Alberta (N.J. Dovichi, 1993); Postdoctoral, Alberta (N.J. Dovichi, J.F. Elliott, 1993-1994), Royal Society of Chemistry Award in Analytical Separation Methods (2001), UBC Charles A. McDowell Award for Excellence in Research (2002), Canadian Society for Chemistry W. A. E. McBryde Medal (2008), Canadian Society for Chemistry Maxxam Award (2015)

Google Scholar Citations

Publications

In Press

Wang, J. ; Zhu, Z. ; Si, L. ; Du, Q. ; Li, H. ; Bi, W. ; Chen, D. D. Y. High Throughput Screening Of Phenoxy Carboxylic Acids With Dispersive Solid Phase Extraction Followed By Direct Analysis In Real Time Mass Spectrometry. Analytica Chimica Acta In Press.
Kovalchik, K. A. ; MacLennan, M. S. ; Peru, K. M. ; Ajaero, C. ; McMartin, D. W. ; Headley, J. V. ; Chen, D. D. Y. Characterization Of Dicarboxylic Naphthenic Acid Fraction Compounds Utilizing Amide Derivatization: Proof Of Concept. Rapid Communications in Mass Spectrometry In Press, n/a–n/a.
Wang, L. ; Yu, L. ; Grist, S. ; Cheung, K. C. ; Chen, D. D. Y. Different In Vitro Cellular Responses To Tamoxifen Treatment In Polydimethylsiloxane-Based Devices Compared To Normal Cell Culture. Journal of Chromatography B In Press.

2017

Cheng, J. ; Wang, L. ; Liu, W. ; Chen, D. D. Y. Quantitative Nonaqueous Capillary Electrophoresis–Mass Spectrometry Method For Determining Active Ingredients In Plant Extracts. Analytical Chemistry 2017, 89, 1411-1415.
Wang, L. ; He, J. ; Yang, Q. ; Li, X. ; Wei, H. ; Chen, D. D. Y. ; Huang, X. A Preliminary Study On The Effects Of Lanthanum (Iii) On Plant Vitronectin-Like Protein And Its Toxicological Basis. Ecotoxicol Environ Saf 2017, 145.
Li, D. ; Zhu, J. ; Wang, M. ; Bi, W. ; Huang, X. ; Chen, D. Da Yong Extraction Of Trace Polychlorinated Biphenyls In Environmental Waters By Well-Dispersed Velvet-Like Magnetic Carbon Nitride Nanocomposites. Journal of Chromatography A 2017, 1491, 27 - 35.
Fan, S. ; Zhu, J. ; Ren, L. ; Wang, M. ; Bi, W. ; Li, H. ; Huang, X. ; Chen, D. Da Yong Co-Solvent Enhanced Adsorption With Magnetic Velvet-Like Carbon Nitride For High Efficiency Solid Phase Extraction. Analytica Chimica Acta 2017, 960, 63 - 71.
Qian, C. ; Kovalchik, K. A. ; MacLennan, M. S. ; Huang, X. ; Chen, D. D. Y. Mobility-Based Correction For Accurate Determination Of Binding Constants By Capillary Electrophoresis-Frontal Analysis. ELECTROPHORESIS 2017, n/a–n/a.
Wang, M. ; Wang, J. ; Zhou, Y. ; Zhang, M. ; Xia, Q. ; Bi, W. ; Chen, D. Da Yong Ecofriendly Mechanochemical Extraction Of Bioactive Compounds From Plants With Deep Eutectic Solvents. ACS Sustainable Chemistry & Engineering 2017, 5.
Kovalchik, K. A. ; MacLennan, M. S. ; Peru, K. M. ; Headley, J. V. ; Chen, D. D. Y. Standard Method Design Considerations For Semi-Quantification Of Total Naphthenic Acids In Oil Sands Process Affected Water By Mass Spectrometry: A Review. Frontiers of Chemical Science and Engineering 2017.
Khodabandehloo, A. ; Chen, D. D. Y. Electroosmotic Flow Dispersion Of Large Molecules In Electrokinetic Migration. Analytical Chemistry 2017, null.
Wang, L. ; He, J. ; Yang, Q. ; Lv, X. ; Li, J. ; Chen, D. D. Y. ; Ding, X. ; Huang, X. ; Zhou, Q. Abnormal Pinocytosis And Valence-Variable Behaviors Of Cerium Suggested A Cellular Mechanism For Plant Yield Reduction Induced By Environmental Cerium. Environmental Pollution 2017, 230, 902 - 910.
Qian, C. ; Fu, H. ; Kovalchik, K. A. ; Li, H. ; Chen, D. Da Yong Specific Binding Constant And Stoichiometry Determination In Free Solution By Mass Spectrometry And Capillary Electrophoresis Frontal Analysis. Analytical Chemistry 2017, null.
Zhou, J. ; Huang, Z. - A. ; Kumar, U. ; Chen, D. D. Y. Review Of Recent Developments In Determining Volatile Organic Compounds In Exhaled Breath As Biomarkers For Lung Cancer Diagnosis. Analytica Chimica Acta 2017, -.
Khodabandehloo, A. ; Chen, D. Da Yong Particle Sizing Methods For The Detection Of Protein Aggregates In Biopharmaceuticals. Bioanalysis 2017, 9, 326.

2016

De Jong, C. A. ; Risley, J. ; Lee, A. K. ; Zhao, S. S. ; Chen, D. D. Y. Separation Of Recombinant Therapeutic Proteins Using Capillary Gel Electrophoresis And Capillary Isoelectric Focusing. In Capillary Electrophoresis of Proteins and Peptides; Capillary Electrophoresis of Proteins and Peptides; Springer Nature: New York, 2016; pp. 137-149.
Risley, J. ; De Jong, C. A. G. ; Chen, D. D. Y. Electrospray Ionization Interface Development For Capillary Electrophoresis–Mass Spectrometry. In Capillary Electrophoresis–Mass Spectrometry (CE-MS); Capillary Electrophoresis–Mass Spectrometry (CE-MS); Wiley-VCH Verlag GmbH & Co. KGaA, 2016; pp. 7–39.
Wang, L. ; Cheng, M. ; Chu, Y. ; Li, X. ; Chen, D. D. Y. ; Huang, X. ; Zhou, Q. Responses Of Plant Calmodulin To Endocytosis Induced By Rare Earth Elements. CHEMOSPHERE 2016, 154, 408-415.
Wang, M. ; Bi, W. ; Huang, X. ; Chen, D. Da Yong Ball Mill Assisted Rapid Mechanochemical Extraction Method For Natural Products From Plants. JOURNAL OF CHROMATOGRAPHY A 2016, 1449, 8-16.
Wang, L. ; MacDonald, D. ; Huang, X. ; Chen, D. D. Y. Capture Efficiency Of Dynamic Ph Junction Focusing In Capillary Electrophoresis. ELECTROPHORESIS 2016, 37, 1143-1150.
Wang, M. ; Wang, J. ; Zhang, Y. ; Xia, Q. ; Bi, W. ; Yang, X. ; Chen, D. Da Yong Fast Environment-Friendly Ball Mill-Assisted Deep Eutectic Solvent-Based Extraction Of Natural Products. JOURNAL OF CHROMATOGRAPHY A 2016, 1443, 262-266.
Ansley, D. M. ; Raedschelders, K. ; Choi, P. T. ; Wang, B. ; Cook, R. C. ; Chen, D. D. Y. Propofol Cardioprotection For On-Pump Aortocoronary Bypass Surgery In Patients With Type 2 Diabetes Mellitus (Pro-Tect Ii): A Phase 2 Randomized-Controlled Trial. CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE 2016, 63, 442-453.
MacLennan, M. S. ; Tie, C. ; Kovalchik, K. ; Peru, K. M. ; Zhang, X. ; Headley, J. V. ; Chen, D. D. Y. Potential Of Capillary Electrophoresis Mass Spectrometry For The Characterization And Monitoring Of Amine-Derivatized Naphthenic Acids From Oil Sands Process-Affected Water. JOURNAL OF ENVIRONMENTAL SCIENCES 2016, 49, 203-212.

2014

Jayo, R. G. ; Thaysen-Andersen, M. ; Lindenburg, P. W. ; Haselberg, R. ; Hankemeier, T. ; Ramautar, R. ; Chen, D. D. Y. Simple Capillary Electrophoresis-Mass Spectrometry Method For Complex Glycan Analysis Using A Flow-Through Microvial Interface. ANALYTICAL CHEMISTRY 2014, 86, 6479-6486.
Lindenburg, P. W. ; Ramautar, R. ; Jayo, R. G. ; Chen, D. D. Y. ; Hankemeier, T. Capillary Electrophoresis-Mass Spectrometry Using A Flow-Through Microvial Interface For Cationic Metabolome Analysis. ELECTROPHORESIS 2014, 35, 1308-1314.
Zhao, S. Sherry; Chen, D. D. Y. Applications Of Capillary Electrophoresis In Characterizing Recombinant Protein Therapeutics. ELECTROPHORESIS 2014, 35, 96-108.

2013

Liu, C. ; Chen, D. D. Y. ; Yu, L. ; Luo, Y. Live Cell Refractometry Based On Non-Spr Microparticle Sensor. ELECTROPHORESIS 2013, 34, 1526-1529.

2012

Soliman, L. C. ; Hui, Y. ; Hewavitharana, A. K. ; Chen, D. D. Y. Monitoring Potential Prostate Cancer Biomarkers In Urine By Capillary Electrophoresis-Tandem Mass Spectrometry. JOURNAL OF CHROMATOGRAPHY A 2012, 1267, 162-169.
Sumer-Bayraktar, Z. ; Nguyen-Khuong, T. ; Jayo, R. ; Chen, D. D. Y. ; Ali, S. ; Packer, N. H. ; Thaysen-Andersen, M. Micro- And Macroheterogeneity Of N-Glycosylation Yields Size And Charge Isoforms Of Human Sex Hormone Binding Globulin Circulating In Serum. PROTEOMICS 2012, 12, 3315-3327.
Jayo, R. G. ; Li, J. ; Chen, D. D. Y. Capillary Electrophoresis Mass Spectrometry For The Characterization Of O-Acetylated N-Glycans From Fish Serum. ANALYTICAL CHEMISTRY 2012, 84, 8756-8762.
Zhao, S. Sherry; Zhong, X. ; Tie, C. ; Chen, D. D. Y. Capillary Electrophoresis-Mass Spectrometry For Analysis Of Complex Samples. PROTEOMICS 2012, 12, 2991-3012.
Hui, Y. ; Zhao, S. Sherry; Love, J. A. ; Ansley, D. M. ; Chen, D. D. Y. Development And Application Of A Lc-Ms/ms Method To Quantify Basal Adenosine Concentration In Human Plasma From Patients Undergoing On-Pump Cabg Surgery. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2012, 885, 30-36.
Hui, Y. ; Wong, M. ; Zhao, S. Sherry; Love, J. A. ; Ansley, D. M. ; Chen, D. D. Y. A Simple And Robust Lc-Ms/ms Method For Quantification Of Free 3-Nitrotyrosine In Human Plasma From Patients Receiving On-Pump Cabg Surgery. ELECTROPHORESIS 2012, 33, 697-704.
Raedschelders, K. ; Ansley, D. M. ; Chen, D. D. Y. The Cellular And Molecular Origin Of Reactive Oxygen Species Generation During Myocardial Ischemia And Reperfusion. PHARMACOLOGY & THERAPEUTICS 2012, 133, 230-255.
Ma, M. ; Kazemzadeh-Narbat, M. ; Hui, Y. ; Lu, S. ; Ding, C. ; Chen, D. D. Y. ; Hancock, R. E. W. ; Wang, R. Local Delivery Of Antimicrobial Peptides Using Self-Organized Tio2 Nanotube Arrays For Peri-Implant Infections. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 2012, 100A, 278-285.

2011

Liu, C. ; Luo, Y. ; Fang, N. ; Chen, D. D. Y. Analyte Distribution At Channel Intersections Of Electro-Fluid-Dynamic Devices. ANALYTICAL CHEMISTRY 2011, 83, 1189-1192.
Zhong, X. ; E. Maxwell, J. ; Ratnayake, C. ; Mack, S. ; Chen, D. D. Y. Flow-Through Microvial Facilitating Interface Of Capillary Isoelectric Focusing And Electrospray Ionization Mass Spectrometry. ANALYTICAL CHEMISTRY 2011, 83, 8748-8755.
Liu, C. ; Luo, Y. ; E. Maxwell, J. ; Fang, N. ; Chen, D. D. Y. Potential Of Two-Dimensional Electro-Fluid-Dynamic Devices For Continuous Purification Of Multiple Components From Complex Samples. ANALYTICAL CHEMISTRY 2011, 83, 8208-8214.
E. Maxwell, J. ; Ratnayake, C. ; Jayo, R. ; Zhong, X. ; Chen, D. D. Y. A Promising Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry Method For Carbohydrate Analysis. ELECTROPHORESIS 2011, 32, 2161-2166.
Zhong, X. ; E. Maxwell, J. ; Chen, D. D. Y. Mass Transport In A Micro Flow-Through Vial Of A Junction-At-The-Tip Capillary Electrophoresis-Mass Spectrometry Interface. ANALYTICAL CHEMISTRY 2011, 83, 4916-4923.
Wang, B. ; Raedschelders, K. ; Shravah, J. ; Hui, Y. ; Safaei, H. G. ; Chen, D. D. Y. ; Cook, R. C. ; Fradet, G. ; Au, C. L. ; Ansley, D. M. Differences In Myocardial Pten Expression And Akt Signalling In Type 2 Diabetic And Nondiabetic Patients Undergoing Coronary Bypass Surgery. CLINICAL ENDOCRINOLOGY 2011, 74, 705-713.

2010

E. Maxwell, J. ; Zhong, X. ; Chen, D. D. Y. Asymmetrical Emitter Geometries For Increased Range Of Stable Electrospray Flow Rates. ANALYTICAL CHEMISTRY 2010, 82, 8377-8381.
Jayo, R. G. ; Chen, D. D. Y. Capillary Electrophoresis Analysis Of Peptides And Proteins Using A Polyethyleneimine-Coated Capillary With Uv And Ms Detection. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2010, 240.
Liu, C. ; Luo, Y. ; Maxwell, E. J. ; Fang, N. ; Chen, D. D. Y. Reverse Of Mixing Process With A Two-Dimensional Electro-Fluid-Dynamic Device. Analytical Chemistry 2010, 82, 2182 - 2185.
Liu, C. ; Park, H. M. ; Monsalve, M. V. ; Chen, D. D. Y. Free Fatty Acids Composition In Adipocere Of The Kwaday Dan Ts'inchi Ancient Remains Found In A Glacier. JOURNAL OF FORENSIC SCIENCES 2010, 55, 1039-1043.
E. Maxwell, J. ; Zhong, X. ; Zhang, H. ; van Zeijl, N. ; Chen, D. D. Y. Decoupling Ce And Esi For A More Robust Interface With Ms. ELECTROPHORESIS 2010, 31, 1130-1137.

2009

Raedschelders, K. ; Hui, Y. ; Laferlita, B. ; Luo, T. ; Zhang, H. ; Chen, D. D. Y. ; Ansley, D. M. Target-Achieved Propofol Concentration During On-Pump Cardiac Surgery: A Pilot Dose-Finding Study. Canadian Journal of Anaesthesia-Journal Canadien D Anesthesie 2009, 56, 658-666.
Wang, B. H. ; Shravah, J. ; Luo, H. L. ; Raedschelders, K. ; Chen, D. D. Y. ; Ansley, D. M. Propofol Protects Against Hydrogen Peroxide-Induced Injury In Cardiac H9C2 Cells Via Akt Activation And Bcl-2 Up-Regulation. Biochemical and Biophysical Research Communications 2009, 389, 105-111.
Cressman, S. ; Sun, Y. ; Maxwell, E. J. ; Fang, N. ; Chen, D. D. Y. ; Cullis, P. R. Binding And Uptake Of Rgd-Containing Ligands To Cellular Alpha(V)Beta(3) Integrins. International Journal of Peptide Research and Therapeutics 2009, 15, 49-59.
Zhong, X. F. ; Yi, R. ; Holliday, A. E. ; Chen, D. D. Y. Field Distribution In An Electrospray Ionization Source Determined By Finite Element Method. Rapid Communications in Mass Spectrometry 2009, 23, 689-697.
Hui, Y. ; Raedschelders, K. ; Zhang, H. ; Ansley, D. M. ; Chen, D. D. Y. Quantitative Analysis Of Propofol In Whole Blood Using Capillary Electrophoresis. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2009, 877, 703-709.

2008

Sun, Y. ; Cressman, S. ; Fang, N. ; Cullis, P. R. ; Chen, D. D. Y. Capillary Electrophoresis Frontal Analysis For Characterization Of Alpha(V)Beta(3) Integrin Binding Interactions. Analytical Chemistry 2008, 80, 3105-3111.
Sun, Y. ; Fang, N. ; Chen, D. D. Y. ; Donkor, K. K. Determination Of Potentially Anti-Carcinogenic Flavonoids In Wines By Micellar Electrokinetic Chromatography. Food Chemistry 2008, 106, 415-420.

2007

Cressman, S. ; Sun, S. ; Dobson, I. T. ; Chen, D. D. Y. ; Cullis, P. R. C. A Two-Site Binding Stoichiometry To Describe Rgd Binding To The Alpha V Beta 3 Integrin. Biopolymers 2007, 88, 634-634.
Fang, N. ; Sun, Y. ; Zheng, J. Y. ; Chen, D. D. Y. Computer Simulation Of Different Modes Of Ace Based On The Dynamic Complexation Model. Electrophoresis 2007, 28, 3214-3222.
Fang, N. ; Meng, P. J. ; Zhang, H. ; Ying, S. ; Chen, D. D. Y. Systematic Optimization Of Exhaustive Electrokinetic Injection Combined With Micellar Sweeping In Capillary Electrophoresis. Analyst 2007, 132, 127-134.

2006

Fang, N. ; Chen, D. D. Y. Behavior Of Interacting Species In Capillary Electrophoresis Described By Mass Transfer Equation. Analytical Chemistry 2006, 78, 1832-1840.
Manisali, I. ; Chen, D. D. Y. ; Schneider, B. B. Electrospray Ionization Source Geometry For Mass Spectrometry: Past, Present, And Future. Trac-Trends in Analytical Chemistry 2006, 25, 243-256.

2005

Fang, N. ; Chen, D. D. Y. General Approach To High-Efficiency Simulation Of Affinity Capillary Electrophoresis. Analytical Chemistry 2005, 77, 840-847.
Fang, N. ; Chen, D. D. Y. Enumeration Algorithm For Determination Of Binding Constants In Capillary Electrophoresis. Analytical Chemistry 2005, 77, 2415-2420.

2004

Fang, N. ; Ting, E. ; Chen, D. D. Y. Determination Of Shapes And Maximums Of Analyte Peaks Based On Solute Mobilitiess In Capillary Electrophoresis. Analytical Chemistry 2004, 76, 1708-1714.
McLaren, D. G. ; Chen, D. D. Y. Continuous Electrophoretic Purification Of Individual Analytes From Multicomponent Mixtures. Analytical Chemistry 2004, 76, 2298-2305.

2003

Britz-McKibbin, P. ; Ichihashi, T. ; Tsubota, K. ; Chen, D. D. Y. ; Terabe, S. Complementary On-Line Preconcentration Strategies For Steroids By Capillary Electrophoresis. Journal of Chromatography A 2003, 1013, 65-76.
Grob, M. K. ; O’Brien, K. ; Chu, J. J. ; Chen, D. D. Y. Optimization Of Cellular Nucleotide Extraction And Sample Preparation For Nucleotide Pool Analyses Using Capillary Electrophoresis. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2003, 788, 103-111.
Galbusera, C. ; Chen, D. D. Y. Molecular Interaction In Capillary Electrophoresis. Current Opinion in Biotechnology 2003, 14, 126-130.

2002

Duso, A. B. ; Chen, D. D. Y. Proton And Hydroxide Ion Mobility In Capillary Electrophoresis. Analytical Chemistry 2002, 74, 2938-2942.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. An Atmospheric Pressure Ion Lens That Improves Nebulizer Assisted Electrospray Ion Sources. Journal of the American Society for Mass Spectrometry 2002, 13, 906-913.
Galbusera, C. ; Thachuk, M. ; De Lorenzi, E. ; Chen, D. D. Y. Affinity Capillary Electrophoresis Using A Low-Concentration Additive With The Consideration Of Relative Mobilities. Analytical Chemistry 2002, 74, 1903-1914.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. Multiple Sprayer System For High-Throughput Electrospray Ionization Mass Spectrometry. Rapid Communications in Mass Spectrometry 2002, 16, 1982-1990.
Britz-McKibbin, P. ; Chen, D. D. Y. Accurately Describing Weak Analyte-Additive Interactions By Capillary Electrophoresis. Electrophoresis 2002, 23, 880-888.
Heegaard, N. H. H. ; Nissen, M. H. ; Chen, D. D. Y. Applications Of On-Line Weak Affinity Interactions In Free Solution Capillary Electrophoresis. Electrophoresis 2002, 23, 815-822.
McLaren, D. G. ; Boulat, O. ; Chen, D. D. Y. Univalent Salts As Modifiers In Micellar Capillary Electrophoresis. Electrophoresis 2002, 23, 1912-1920.

2001

Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. Collision-Induced Dissociation Of Bradykinin Ions In The Interface Region Of An Esi-Ms. Journal of the American Society for Mass Spectrometry 2001, 12, 772-779.
Schneider, B. B. ; Douglas, D. J. ; Chen, D. D. Y. An Atmospheric Pressure Ion Lens To Improve Electrospray Ionization At Low Solution Flow-Rates. Rapid Communications in Mass Spectrometry 2001, 15, 2168-2175.

2000

Schneider, B. B. ; Chen, D. D. Y. Collision-Induced Dissociation Of Ions Within The Orifice-Skimmer Region Of An Electrospray Mass Spectrometer. Analytical Chemistry 2000, 72, 791-799.
Britz-McKibbin, P. ; Bebault, G. M. ; Chen, D. D. Y. Velocity-Difference Induced Focusing Of Nucleotides In Capillary Electrophoresis With A Dynamic Ph Junction. Analytical Chemistry 2000, 72, 1729-1735.

1999

Britz-McKibbin, P. ; Wong, J. ; Chen, D. D. Y. Analysis Of Epinephrine From Fifteen Different Dental Anesthetic Formulations By Capillary Electrophoresis. Journal of Chromatography A 1999, 853, 535-540.
Britz-McKibbin, P. ; Vo, H. C. ; MacGillivray, R. T. A. ; Chen, D. D. Y. Analysis Of Gamma-Carboxyglutamic Acid Content Of Protein, Urine, And Plasma By Capillary Electrophoresis And Laser-Induced Fluorescence. Analytical Chemistry 1999, 71, 1633-1637.

1998

Kranack, A. R. ; Bowser, M. T. ; Britz-McKibbin, P. ; Chen, D. D. Y. The Effects Of A Mixture Of Charged And Neutral Additives On Analyte Migration Behavior In Capillary Electrophoresis. Electrophoresis 1998, 19, 388-396.
Bowser, M. T. ; Kranack, A. R. ; Chen, D. D. Y. Properties Of Multivariate Binding Isotherms In Capillary Electrophoresis. Analytical Chemistry 1998, 70, 1076-1084.
Britz-McKibbin, P. ; Kranack, A. R. ; Paprica, A. ; Chen, D. D. Y. Quantitative Assay Fdr Epinephrine In Dental Anesthetic Solutions By Capillary Electrophoresis. Analyst 1998, 123, 1461-1463.
Bowser, M. T. ; Chen, D. D. Y. Recent Developments Towards A Unified Theory For Separation Science. Electrophoresis 1998, 19, 1586-1589.
Lucy, C. A. ; Yeung, K. K. C. ; Pang, X. J. ; Chen, D. D. Y. Extraseparation Peak Broadening In Capillary Electrophoresis. Lc Gc-Magazine of Separation Science 1998, 16, 26-+.
Bowser, M. T. ; Kranack, A. R. ; Chen, D. D. Y. Analyte-Additive Interactions In Nonaqueous Capillary Electrophoresis: A Critical Review. Trac-Trends in Analytical Chemistry 1998, 17, 424-434.
Bowser, M. T. ; Chen, D. D. Y. Higher Order Equilibria And Their Effect On Analyte Migration Behavior In Capillary Electrophoresis. Analytical Chemistry 1998, 70, 3261-3270.
Bowser, M. T. ; Chen, D. D. Y. Dynamic Complexation Of Solutes In Capillary Electrophoresis. Electrophoresis 1998, 19, 383-387.

1997

BritzMcKibbin, P. ; Chen, D. D. Y. Prediction Of The Migration Behavior Of Analytes In Capillary Electrophoresis Based On Three Fundamental Parameters. Journal of Chromatography A 1997, 781, 23-34.
Peng, X. J. ; Bowser, M. T. ; BritzMcKibbin, P. ; Bebault, G. M. ; Morris, J. R. ; Chen, D. D. Y. Quantitative Description Of Analyte Migration Behavior Based On Dynamic Complexation In Capillary Electrophoresis With One Or More Additives. Electrophoresis 1997, 18, 706-716.
Peng, X. J. ; Bebault, G. M. ; Sacks, S. L. ; Chen, D. D. Y. Quantitative Description Of Analyte Migration Behavior Based On The Dynamic Complexation Model In Capillary Electrophoresis. Canadian Journal of Chemistry-Revue Canadienne De Chimie 1997, 75, 507-517.
Bowser, M. T. ; Bebault, G. M. ; Peng, X. J. ; Chen, D. D. Y. Redefining The Separation Factor: A Potential Pathway To A Unified Separation Science. Electrophoresis 1997, 18, 2928-2934.
Peng, X. J. ; Chen, D. D. Y. Variance Contributed By Pressure Induced Injection In Capillary Electrophoresis. Journal of Chromatography A 1997, 767, 205-216.

1996

Bowser, M. T. ; Sternberg, E. D. ; Chen, D. D. Y. Development And Application Of A Nonaqueous Capillary Electrophoresis System For The Analysis Of Porphyrins And Their Oligomers (Photofrin). Analytical Biochemistry 1996, 241, 143-150.