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Cladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis

TitleCladoniamides A-G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis
Publication TypeJournal Article
Year of Publication2008
AuthorsWilliams, DE, Davies, J, Patrick, BO, Bottriell, H, Tarling, T, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume10
Pagination3501-3504
Date PublishedAug
Type of ArticleArticle
ISBN Number1523-7060
Keywordsbiosynthesis, CHROMOPYRROLIC ACID, REBECCAMYCIN
Abstract

Cladoniamides A-G (3-9) have been isolated from cultures of Streptomyces uncialis, and their structures have been elucidated by a combination of spectroscopic analysis and an X-ray diffraction analysis of cladoniamide A (3). The cladoniamides have unprecedented rearranged and degraded alkaloid skeletons with putative biogenetic origins from indolocarbazole precursors. Cladoniamide G (9) is cytotoxic to MCF-7 cells in vitro at 10 mu g/mL.

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