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Cationic technetium and rhenium complexes with pendant carbohydrates.

TitleCationic technetium and rhenium complexes with pendant carbohydrates.
Publication TypeJournal Article
Year of Publication2010
AuthorsFerreira, CL, Marques, FLN, Okamoto, MRY, Otake, AH, Sugai, Y, Mikata, Y, Storr, T, Bowen, M, Yano, S, Adam, MJ, Chammas, R, Orvig, C
JournalApplied Radiation and Isotopes
Volume68
Pagination1087 - 1093
Date Published2010///
ISBN Number0969-8043
Keywordsisotope labeling technetium rhenium glucopyranoside pyridylaminoethyl deriv carbonyl complex, technetium rhenium glucopyranoside pyridylaminoethyl deriv carbonyl complex prepn biodistribution
Abstract

Rhenium(I) and technetium(I) complexes with three dipicolylamine carbohydrate-conjugated chelators (L), 2-bis(2-pyridinylmethyl)aminoethyl-1-deoxy-1-thio-β-D-glucopyranoside (L1), O1-2-bis(2-pyridinylmethyl)aminoethyl-β-D-glucopyranoside (L2), and N-(2-bis(2-pyridinylmethyl)carboxamido-2-deoxy-D-glucopyranose) (L3) M(CO)3L+ (M = Tc, Re) were formed by complexing to the [M(CO)3]+ core and the properties of the resulting complexes were investigated. Synthesis and characterization of the chelator L1 and the corresponding Re complex are reported. All chelators were radiolabeled in high yield with [99mTc(CO)3(H2O)3]+ (>98%) and [186Re(CO)3(H2O)3]+ (>80%). The chelators and Re-complexes were detd. to not be substrates for the glucose metab. enzyme hexokinase. However, the biodistribution of each of the 99mTc complexes demonstrated fast clearance from most background tissue, including >75% clearance of the activity in the kidneys and the liver within 2 h post-injection. [on SciFinder(R)]