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Caminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia

TitleCaminoside A, an antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia
Publication TypeJournal Article
Year of Publication2002
AuthorsLinington, RG, Robertson, M, Gauthier, A, Finlay, BB, van Soes, R, Andersen, RJ
JournalOrganic Letters
Volume4
Pagination4089-4092
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsENTEROPATHOGENIC ESCHERICHIA-COLI, HOST-CELLS, PROTEIN, RECEPTOR, SECRETION, SYSTEMS
Abstract

[GRAPHICS] Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycollpid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.

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