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Bogorol A produced in culture by a marine Bacillus sp reveals a novel template for cationic peptide antibiotics

TitleBogorol A produced in culture by a marine Bacillus sp reveals a novel template for cationic peptide antibiotics
Publication TypeJournal Article
Year of Publication2001
AuthorsBarsby, T, Kelly, MT, Gagne, SM, Andersen, RJ
JournalOrganic Letters
Volume3
Pagination437-440
Date PublishedFeb
Type of ArticleArticle
ISBN Number1523-7060
KeywordsBACTERIUM, DEFENSINS, HELIX, resistance
Abstract

[GRAPHICS] Bogorol A (1), a novel peptide antibiotic active against MRSA and VRE, has been isolated from cultures of a marine Bacillus sp, collected in Papua New Guinea, The structure of bogorol A was elucidated by a combination of spectroscopic analyses and chemical degradation. Bogorol A illustrates a new structural template for "cationic peptide antibiotics".

URL<Go to ISI>://000166778800032