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Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy.

TitleBafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy.
Publication TypeJournal Article
Year of Publication2010
AuthorsCarr, G, Williams, DE, Diaz-Marrero, AR, Patrick, BO, Bottriell, H, Balgi, AD, Donohue, E, Roberge, M, Andersen, RJ
JournalJournal of Natural Products
Volume73
Pagination422 - 427
Date Published2010///
ISBN Number0163-3864
KeywordsStreptomyces bafilomycin isolation autophagy inhibitor
Abstract

Five new bafilomycins, F (1) to J (5), have been isolated from lab. cultures of two Streptomyces spp. obtained from marine sediments collected in British Columbia, and their structures have been elucidated by detailed anal. of spectroscopic data and the synthesis of model compds. The new bafilomycins F (1), G (2), H (3), and J (5) along with several co-occurring known analogs showed potent inhibition of autophagy in microscopy and biochem. assays. The thiomorpholinone fragment present in bafilomycin F (1) has not previously been found in a natural product. [on SciFinder(R)]