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Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp

TitleAvinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp
Publication TypeJournal Article
Year of Publication2006
AuthorsDiaz-Marrero, AR, Austin, P, Van Soest, R, Matainaho, T, Roskelley, CD, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume8
Pagination3749-3752
Date PublishedAug
Type of ArticleArticle
ISBN Number1523-7060
KeywordsANTI-INVASION, AVAROL, INHIBITOR, KINASE, MIGRATION, PROTEOLYSIS, SESQUITERPENE QUINONES, STRESS FIBERS, STRONGYLOPHORINE-26, TUMOR-CELL INVASION
Abstract

The new meroterpenoids avinosol (1),3 ’-aminoavarone (2), and 3 ’-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example of a naturally occurring meroterpenoid-nucleoside conjugate, showed antiinvasion activity in a cell-based assay.

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