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Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1.

TitleAustralin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5-Phosphatase SHIP1.
Publication TypeJournal Article
Year of Publication2010
AuthorsWilliams, DE, Amlani, A, Dewi, AS, Patrick, BO, van Ofwegen, L, Mui, AL-F, Andersen, RJ
JournalAustralian Journal of Chemistry
Volume63
Pagination895 - 900
Date Published2010///
ISBN Number0004-9425
KeywordsCladiella diterpene
Abstract

Four new diterpenoids, australins E-H (I-IV), have been isolated from the marine soft coral Cladiella sp. collected in Pohnpei. The structures of 1-4 were elucidated by anal. of their NMR and mass spectrometry data combined with an X-ray diffraction anal. of australin E. Australin E activates the inositol 5-phosphatase SHIP1 in vitro. [on SciFinder(R)]