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An atmospheric pressure ion lens that improves nebulizer assisted electrospray ion sources

TitleAn atmospheric pressure ion lens that improves nebulizer assisted electrospray ion sources
Publication TypeJournal Article
Year of Publication2002
AuthorsSchneider, BB, Douglas, DJ, Chen, DDY
JournalJournal of the American Society for Mass Spectrometry
Volume13
Pagination906-913
Date PublishedAug
Type of ArticleArticle
ISBN Number1044-0305
KeywordsCAPILLARY-ZONE-ELECTROPHORESIS, DISSOCIATION, EVAPORATION, IDENTIFICATION, INDUCED, INTERFACE, IONIZATION MASS-SPECTROMETRY, JUNCTION, MECHANISM, PROTEIN-ANALYSIS, SHEATHLESS
Abstract

An atmospheric pressure ion lens improves the performance and ease of use of a nebulizer assisted electrospray (ion spray) ion source. The lens is comprised of an oblong-shaped stainless steel ring attached to an external high voltage power supply. The lens is located near the tip of the conductive sprayer, and is maintained at a potential less than that of the sprayer. The ion lens improves the shape of the equipotential lines in the vicinity of the sprayer tip. This lens gives approximately a 2-fold reduction in the signal RSD, a 2-fold increase in the ion signal, an increase in the number of multiply charged ions, and a much broader range of usable sprayer positions. (C) 2002 American Society for Mass Spectrometry.

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