|Title||1-Deoxygalactonojirimycin-lysine hybrids as potent D-galactosidase inhibitors|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Steiner, AJ, Schitter, G, Stuetz, AE, Wrodnigg, TM, Tarling, CA, Withers, SG, Fantur, K, Mahuran, D, Paschke, E, Tropak, M|
|Journal||BIOORGANIC & MEDICINAL CHEMISTRY|
|Date Published||DEC 15|
Cyclization by double reductive amination of L-arabino-hexos-5-ulose with suitably protected D- as well as L-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5. Modi. cations on the lysine moiety by acylation gave access to lipophilic derivatives which exhibited excellent D-galactosidase inhibitory activities. (C) 2008 Elsevier Ltd. All rights reserved.